SLCO4A1

Across TCGA patient cohorts, SLCO4A1 mutation is significantly associated with the RNA expression of many other genes, with 1,344 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO4A1-associated genes across cancer lineages are RNF19BPY, IGHVII-67-1, and RNU1-75P. Each is linked with SLCO4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO4A1-to-partner and partner-to-SLCO4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF19BPY grouped by SLCO4A1-low versus SLCO4A1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO4A1→partner) and Y-score (partner→SLCO4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF19BPY →	+0.027	+5.368	<.001	.005	3	2
HNSC	IGHVII-67-1 →	+0.828	+6.763	<.001	<.001	3	2
CESC	RNU1-75P →	+0.399	+3.996	.008	.005	3	2
UCEC	MIR3661 →	+0.479	+1.309	<.001	.007	3	2
UCEC	KCTD9 →	+0.632	+2.436	<.001	.001	3	2
UCEC	GALNT6 →	-0.615	-1.530	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,344 associations by consensus.

RNF19BPY by SLCO4A1 expression — HNSC

Explore this box plot interactively →