SLCO4A1

Across TCGA cell cohorts, SLCO4A1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLCO4A1-associated genes across cancer lineages are OR10W1, APOA5, and NPY5R. Each is linked with SLCO4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO4A1-to-partner and partner-to-SLCO4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by SLCO4A1-low versus SLCO4A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO4A1→partner) and Y-score (partner→SLCO4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
BLOOD_Lymphoma	APOA5 →	+0.030	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	NPY5R →	+0.012	+4.350	.009	.005	3	1
BLOOD_Lymphoma	SPANXC →	+0.329	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	KRTAP4-8 →	+0.025	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	KRTAP4-7 →	+0.078	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR10W1 by SLCO4A1 expression — LARGE_INTESTINE

Explore this box plot interactively →