SLCO3A1

Across TCGA cell cohorts, SLCO3A1 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO3A1-associated genes across cancer lineages are TRPC7, PEBP4, and CT45A6. Each is linked with SLCO3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO3A1-to-partner and partner-to-SLCO3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPC7 grouped by SLCO3A1-low versus SLCO3A1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO3A1→partner) and Y-score (partner→SLCO3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TRPC7 →	+0.068	+3.807	.001	.003	3	1
STOMACH	PEBP4 →	+0.137	+3.584	.005	.009	3	1
STOMACH	CT45A6 →	+0.031	+3.662	<.001	.001	3	1
LARGE_INTESTINE	TNFRSF10A →	+0.803	+3.588	.005	<.001	3	1
LARGE_INTESTINE	C12orf57 →	+0.798	+3.169	.003	.009	3	1
LARGE_INTESTINE	SEMG2 →	+0.362	+2.041	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

TRPC7 by SLCO3A1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →