SLCO2A1

Across TCGA patient cohorts, SLCO2A1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO2A1-associated genes across cancer lineages are Caspase-7-cleavedD198, p62 Lck ligand, and PDCD4. Each is linked with SLCO2A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO2A1-to-partner and partner-to-SLCO2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLCO2A1-low versus SLCO2A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO2A1→partner) and Y-score (partner→SLCO2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.982	+2.815	.023	.036	3	3
UCEC	p62 Lck ligand →	+0.376	+2.700	<.001	.005	3	2
UCEC	PDCD4 →	-0.434	-2.321	.007	.033	3	2
UCEC	ASNS →	+0.370	+1.415	.003	.043	3	2
UCEC	Caspase-8 →	-0.275	-2.459	.001	<.001	3	2
LUSC	GSK3-a-b →	+0.178	+2.468	.019	.011	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by SLCO2A1 expression — COAD

Explore this box plot interactively →