SLCO1C1

Across TCGA patient cohorts, SLCO1C1 mutation is significantly associated with the RNA expression of many other genes, with 3,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1C1-associated genes across cancer lineages are PDHA1, UQCRC1, and AKAP1. Each is linked with SLCO1C1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLCO1C1-to-partner and partner-to-SLCO1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDHA1 grouped by SLCO1C1-low versus SLCO1C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1C1→partner) and Y-score (partner→SLCO1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDHA1 →	+0.405	+2.343	.002	<.001	3	4
SKCM	UQCRC1 →	+0.267	+1.536	.008	.002	3	3
SKCM	AKAP1 →	+0.412	+1.786	.002	<.001	3	3
SKCM	RAN →	+0.353	+1.575	.001	.002	3	3
SKCM	DPH2 →	+0.373	+1.353	.001	.007	3	3
UCEC	RAD51 →	+0.672	+1.936	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,068 associations by consensus.

PDHA1 by SLCO1C1 expression — UCEC

Explore this box plot interactively →