SLCO1C1

Across TCGA patient cohorts, SLCO1C1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1C1-associated genes across cancer lineages are ASNS, Cyclin-E2, and RBM15. Each is linked with SLCO1C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO1C1-to-partner and partner-to-SLCO1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SLCO1C1-low versus SLCO1C1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1C1→partner) and Y-score (partner→SLCO1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ASNS →	+0.627	+3.321	<.001	.010	3	3
BLCA	Cyclin-E2 →	+0.248	+2.845	.004	.033	3	3
BLCA	RBM15 →	+0.512	+3.321	.014	.010	3	2
UCEC	Rab25 →	-0.411	-1.584	.001	.036	3	2
LUSC	DJ-1 →	-0.132	-3.321	.046	.009	3	2
UCEC	Notch1 →	+0.152	+2.335	.006	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ASNS by SLCO1C1 expression — BLCA

Explore this box plot interactively →