SLCO1C1

Across TCGA cell cohorts, SLCO1C1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLCO1C1-associated genes across cancer lineages are GJD2, TFDP3, and OR2L5. Each is linked with SLCO1C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO1C1-to-partner and partner-to-SLCO1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by SLCO1C1-low versus SLCO1C1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1C1→partner) and Y-score (partner→SLCO1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TFDP3 →	+0.025	+3.196	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.011	+5.472	<.001	<.001	3	1
LUNG_SCLC	WFDC12 →	+0.198	+4.523	<.001	.003	3	1
LUNG_SCLC	GJE1 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	KRTAP4-8 →	+0.027	+4.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GJD2 by SLCO1C1 expression — LARGE_INTESTINE

Explore this box plot interactively →