Across TCGA patient cohorts, SLCO1B7 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SLCO1B7-associated genes across cancer lineages are AMPK_alpha, Src, and PREX1. Each is linked with SLCO1B7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO1B7-to-partner and partner-to-SLCO1B7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B7→partner) and Y-score (partner→SLCO1B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AMPK_alpha →	+0.304	+3.000	<.001	.035	3	1
SKCM	Src →	-0.467	-3.000	<.001	.036	3	1
SKCM	PREX1 →	-0.465	-3.000	.012	.035	2	1
SKCM	eIF4E →	+0.254	+3.000	.012	.036	1	1
SKCM	PDK1 →	+0.167	+3.051	.007	.018	1	1
SKCM	Syk →	-0.700	-3.000	.012	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

SLCO1B7 survival (RNA) · tumor vs normal (RNA) · all SLCO1B7 data types