SLCO1B1

Across TCGA patient cohorts, SLCO1B1 mutation is significantly associated with the RNA expression of many other genes, with 4,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1B1-associated genes across cancer lineages are RNU4-65P, POC1A, and AUNIP. Each is linked with SLCO1B1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLCO1B1-to-partner and partner-to-SLCO1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-65P grouped by SLCO1B1-low versus SLCO1B1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B1→partner) and Y-score (partner→SLCO1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU4-65P →	+0.225	+5.257	<.001	.002	3	4
UCEC	POC1A →	+0.612	+2.115	<.001	<.001	3	4
UCEC	AUNIP →	+0.758	+2.432	<.001	<.001	3	4
SKCM	CNOT3 →	+0.296	+2.453	<.001	.001	3	3
SKCM	KIF9 →	+0.334	+2.453	.001	.001	3	3
UCEC	EME1 →	+0.663	+2.126	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,958 associations by consensus.

RNU4-65P by SLCO1B1 expression — READ

Explore this box plot interactively →