SLCO1B1

Across TCGA patient cohorts, SLCO1B1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO1B1-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and FoxM1. Each is linked with SLCO1B1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLCO1B1-to-partner and partner-to-SLCO1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLCO1B1-low versus SLCO1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B1→partner) and Y-score (partner→SLCO1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.702	+1.604	<.001	.010	3	4
LUSC	14-3-3_beta →	-0.112	-2.078	.005	.005	3	2
UCEC	FoxM1 →	+0.238	+1.716	.004	.003	3	2
LUSC	HER2 →	+0.445	+1.687	<.001	.013	3	2
UCEC	p70-S6K_pT389 →	-0.193	-2.000	.001	.029	3	2
UCEC	Cyclin-B1 →	+0.796	+2.700	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Caspase-7-cleavedD198 by SLCO1B1 expression — UCEC

Explore this box plot interactively →