SLCO1B1

Across TCGA cell cohorts, SLCO1B1 mutation is significantly associated with the RNA expression of many other genes, with 173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO1B1-associated genes across cancer lineages are RPL9, OR4F4, and MAGEB4. Each is linked with SLCO1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO1B1-to-partner and partner-to-SLCO1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL9 grouped by SLCO1B1-low versus SLCO1B1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO1B1→partner) and Y-score (partner→SLCO1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPL9 →	+0.622	+3.451	.005	.002	3	2
LARGE_INTESTINE	OR4F4 →	+0.013	+2.425	<.001	.004	3	2
LUNG_NSCLC_LUAD	MAGEB4 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	C9orf92 →	+0.217	+4.212	<.001	.007	3	1
SKIN	H2BW2 →	+0.074	+2.882	<.001	.005	3	1
SKIN	CPA5 →	+0.438	+2.729	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 173 associations by consensus.

RPL9 by SLCO1B1 expression — LARGE_INTESTINE

Explore this box plot interactively →