SLC9C2

Across TCGA pan-cancer cohorts, SLC9C2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SLC9C2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SLC9C2 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC9C2 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and UCEC are the cancer types where SLC9C2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC9C2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−0.273	<.001	9	view →
KICH	All	All	−0.174	<.001	9	view →
UCEC	All	II,III,IV	−0.630	.004	6	view →
LUAD	Female	II,III,IV	−0.260	<.001	4	view →
THCA	Male	All	−0.056	.001	3	view →
HNSC	Male	All	+0.014	.009	3	view →
LIHC	All	All	+0.183	.005	2	view →
BRCA	All	III,IV	−0.045	<.001	2	view →
PRAD	All	All	−0.031	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SLC9C2–LUSC

Open the LUSC breakdown →