SLC9C1

Across TCGA cell cohorts, SLC9C1 mutation is significantly associated with the RNA expression of many other genes, with 426 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC9C1-associated genes across cancer lineages are SH3GL2, PDS5A, and GCH1. Each is linked with SLC9C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC9C1-to-partner and partner-to-SLC9C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by SLC9C1-low versus SLC9C1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9C1→partner) and Y-score (partner→SLC9C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.148	+2.465	<.001	.007	3	2
LARGE_INTESTINE	PDS5A →	+0.714	+3.364	<.001	.002	3	2
LARGE_INTESTINE	GCH1 →	+0.726	+3.364	<.001	.002	3	2
LARGE_INTESTINE	ZNF232 →	+0.803	+3.364	.001	.002	3	2
SKIN	CYP26C1 →	+0.101	+3.228	.008	.003	3	2
SKIN	IL31 →	+0.017	+3.562	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 426 associations by consensus.

SH3GL2 by SLC9C1 expression — LARGE_INTESTINE

Explore this box plot interactively →