Across TCGA pan-cancer cohorts, SLC9B1P2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SLC9B1P2’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC9B1P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC9B1P2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.
HNSC, KIRP, and KICH are the cancer types where SLC9B1P2 tumor–normal differential expression is most reproducible.