SLC9A9

Across TCGA pan-cancer cohorts, SLC9A9 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLC9A9 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLC9A9 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC9A9 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and ESCA are the cancer types where SLC9A9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.124	0.706	<.001	24	view →
UCEC	DFS	Median	III,IV	0.915	0.532	.035	8	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLC9A9–ACC (OS)

Open the ACC breakdown →