SLC9A5

Across TCGA patient cohorts, SLC9A5 mutation is significantly associated with the RNA expression of many other genes, with 4,504 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC9A5-associated genes across cancer lineages are TYMS, OR5K1, and SMIM4. Each is linked with SLC9A5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC9A5-to-partner and partner-to-SLC9A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by SLC9A5-low versus SLC9A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9A5→partner) and Y-score (partner→SLC9A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMS →	+0.613	+1.459	<.001	.001	3	4
LGG	OR5K1 →	+0.069	+5.392	<.001	.005	3	3
SKCM	SMIM4 →	+0.497	+2.421	.004	.002	3	3
SKCM	RNASEH1 →	+0.545	+2.835	<.001	.001	3	3
SKCM	PPIH →	+0.454	+3.198	<.001	.009	3	3
UCEC	THOP1 →	+0.505	+2.010	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,504 associations by consensus.

TYMS by SLC9A5 expression — UCEC

Explore this box plot interactively →