SLC9A4

Across TCGA patient cohorts, SLC9A4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC9A4-associated genes across cancer lineages are Caspase-7-cleavedD198, YAP_pS127, and Cyclin-B1. Each is linked with SLC9A4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC9A4-to-partner and partner-to-SLC9A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC9A4-low versus SLC9A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9A4→partner) and Y-score (partner→SLC9A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.792	+2.604	<.001	<.001	3	5
LUAD	YAP_pS127 →	-0.445	-2.459	.007	.020	3	3
UCEC	Cyclin-B1 →	+0.602	+3.459	.001	.005	3	3
LUAD	C-Raf →	+0.105	+2.824	.033	.034	3	2
STAD	Cyclin-E2 →	+0.171	+3.021	.014	.018	3	2
STAD	E-Cadherin →	+0.871	+3.000	.033	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by SLC9A4 expression — UCEC

Explore this box plot interactively →