SLC9A3R2

Across TCGA patient cohorts, SLC9A3R2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC9A3R2-associated genes across cancer lineages are HER3, p90 RSK_pT359_S363, and Rad50. Each is linked with SLC9A3R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC9A3R2-to-partner and partner-to-SLC9A3R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by SLC9A3R2-low versus SLC9A3R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9A3R2→partner) and Y-score (partner→SLC9A3R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	+0.477	+3.013	<.001	.018	3	1
UCEC	p90 RSK_pT359_S363 →	+0.350	+2.817	<.001	.036	3	1
UCEC	Rad50 →	-0.330	-3.321	.009	.010	3	1
UCEC	Annexin-1 →	+0.725	+2.827	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

HER3 by SLC9A3R2 expression — UCEC

Explore this box plot interactively →