SLC9A2

Across TCGA patient cohorts, SLC9A2 mutation is significantly associated with the RNA expression of many other genes, with 4,351 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC9A2-associated genes across cancer lineages are PPP4C, MED8, and SSU72. Each is linked with SLC9A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC9A2-to-partner and partner-to-SLC9A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP4C grouped by SLC9A2-low versus SLC9A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9A2→partner) and Y-score (partner→SLC9A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP4C →	+0.286	+2.101	.006	<.001	3	3
UCEC	MED8 →	+0.298	+2.101	.001	<.001	3	3
SKCM	SSU72 →	+0.294	+2.084	<.001	<.001	3	3
UCEC	BOLA3 →	+0.383	+2.502	<.001	.001	3	3
UCEC	RNF25 →	+0.273	+2.526	.002	.001	3	3
UCEC	CDK5 →	+0.461	+2.400	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,351 associations by consensus.

PPP4C by SLC9A2 expression — UCEC

Explore this box plot interactively →