SLC9A2

Across TCGA patient cohorts, SLC9A2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC9A2-associated genes across cancer lineages are LKB1, PDCD4, and PKC-delta_pS664. Each is linked with SLC9A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC9A2-to-partner and partner-to-SLC9A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by SLC9A2-low versus SLC9A2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9A2→partner) and Y-score (partner→SLC9A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LKB1 →	+0.243	+3.505	<.001	.002	3	2
UCEC	PDCD4 →	-0.699	-2.000	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.098	-2.990	.012	<.001	3	2
UCEC	Rab25 →	-0.425	-2.000	<.001	<.001	3	2
UCEC	S6 →	+0.192	+3.459	.026	.005	3	2
UCEC	c-Met_pY1235 →	+0.057	+1.459	.017	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

LKB1 by SLC9A2 expression — LUSC

Explore this box plot interactively →