SLC9A1

Across TCGA patient cohorts, SLC9A1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC9A1-associated genes across cancer lineages are MEK1, NF2, and ASNS. Each is linked with SLC9A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC9A1-to-partner and partner-to-SLC9A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC9A1-low versus SLC9A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC9A1→partner) and Y-score (partner→SLC9A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.398	+1.893	<.001	<.001	3	3
UCEC	NF2 →	+0.240	+2.321	<.001	.005	3	3
COAD	ASNS →	+0.599	+2.815	.005	.036	3	2
UCEC	eEF2 →	+0.299	+1.765	.007	.011	3	2
UCEC	A-Raf_pS299 →	-0.130	-2.115	<.001	.016	3	2
UCEC	ERK2 →	+0.168	+1.662	.004	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MEK1 by SLC9A1 expression — UCEC

Explore this box plot interactively →