SLC8A3

Across TCGA patient cohorts, SLC8A3 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC8A3-associated genes across cancer lineages are GAPDH, Cyclin-B1, and PKC-delta_pS664. Each is linked with SLC8A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC8A3-to-partner and partner-to-SLC8A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SLC8A3-low versus SLC8A3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8A3→partner) and Y-score (partner→SLC8A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.515	+3.169	<.001	<.001	3	5
UCEC	Cyclin-B1 →	+0.671	+2.662	<.001	<.001	3	4
COAD	PKC-delta_pS664 →	-0.182	-3.152	<.001	.017	3	4
UCEC	c-Jun_pS73 →	-0.115	-1.794	.013	.024	3	4
LUAD	GATA3 →	-0.106	-2.222	.045	.010	3	3
UCEC	JNK_pT183_Y185 →	-0.134	-1.584	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

GAPDH by SLC8A3 expression — SKCM

Explore this box plot interactively →