SLC8A3

Across TCGA cell cohorts, SLC8A3 mutation is significantly associated with the RNA expression of many other genes, with 174 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SLC8A3-associated genes across cancer lineages are RESP18, XAGE2, and ID2. Each is linked with SLC8A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC8A3-to-partner and partner-to-SLC8A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RESP18 grouped by SLC8A3-low versus SLC8A3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8A3→partner) and Y-score (partner→SLC8A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RESP18 →	+0.072	+5.169	<.001	.005	3	2
LUNG_NSCLC_LUAD	XAGE2 →	+2.282	+2.754	<.001	.008	3	2
SKIN	ID2 →	+1.713	+2.459	<.001	.006	3	2
SKIN	STAB2 →	+0.444	+2.628	.001	.002	3	2
LUNG_NSCLC_LUSC	C7orf33 →	+0.290	+3.000	.002	.006	3	1
LUNG_NSCLC_LUSC	ORM1 →	+0.175	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 174 associations by consensus.

RESP18 by SLC8A3 expression — BREAST

Explore this box plot interactively →