SLC8A2

Across TCGA patient cohorts, SLC8A2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC8A2-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and MEK1. Each is linked with SLC8A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC8A2-to-partner and partner-to-SLC8A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SLC8A2-low versus SLC8A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC8A2→partner) and Y-score (partner→SLC8A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.142	+1.247	.030	.045	3	2
UCEC	JNK_pT183_Y185 →	-0.199	-2.124	<.001	.001	3	2
UCEC	MEK1 →	+0.402	+2.700	.001	.005	3	2
UCEC	Mre11 →	-0.068	-1.973	.020	.029	3	2
UCEC	Myosin-IIa_pS1943 →	+0.143	+1.261	.042	.029	3	2
UCEC	PCNA →	+0.232	+1.514	.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ERK2 by SLC8A2 expression — UCEC

Explore this box plot interactively →