SLC7A7

Across TCGA patient cohorts, SLC7A7 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A7-associated genes across cancer lineages are Chk2_pT68, EGFR_pY1068, and ERK2. Each is linked with SLC7A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A7-to-partner and partner-to-SLC7A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by SLC7A7-low versus SLC7A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A7→partner) and Y-score (partner→SLC7A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.165	-1.807	.031	.027	3	2
UCEC	EGFR_pY1068 →	-0.291	-3.459	.004	.005	3	1
UCEC	ERK2 →	+0.235	+3.169	.003	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-2.105	.023	.017	3	1
UCEC	JNK2 →	+0.245	+2.179	.002	.034	3	1
UCEC	MEK1 →	+0.404	+2.321	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Chk2_pT68 by SLC7A7 expression — UCEC

Explore this box plot interactively →