SLC7A7

Across TCGA cell cohorts, SLC7A7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,682 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC7A7-associated GO terms across cancer lineages are Regulation of transforming growth factor beta production, Negative regulation of response to type II interferon, and Negative regulation of type II interferon-mediated signaling pathway. Each is linked with SLC7A7 in more than 7 cancer types. Because this analysis shows association rather than direction, both SLC7A7-to-partner and partner-to-SLC7A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transforming growth factor beta production grouped by SLC7A7-low versus SLC7A7-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A7→partner) and Y-score (partner→SLC7A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of transforming growth factor beta production →	+0.155	+1.687	.003	.003	3	8
LARGE_INTESTINE	Negative regulation of response to type II interferon →	+0.228	+2.778	<.001	<.001	3	8
LARGE_INTESTINE	Negative regulation of type II interferon-mediated signaling pathway →	+0.228	+2.778	<.001	<.001	3	8
OVARY	Protein localization to endoplasmic reticulum →	+0.107	+1.865	<.001	.002	3	8
BREAST	Cellular response to type I interferon →	+0.116	+0.882	<.001	.002	3	7
LARGE_INTESTINE	Astrocyte activation →	+0.176	+2.250	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,682 associations by consensus.

Regulation of transforming growth factor beta production by SLC7A7 expression — STOMACH

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