SLC7A5

Across TCGA patient cohorts, SLC7A5 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A5-associated genes across cancer lineages are EGFR_pY1068, GATA6, and Heregulin. Each is linked with SLC7A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A5-to-partner and partner-to-SLC7A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SLC7A5-low versus SLC7A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A5→partner) and Y-score (partner→SLC7A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.233	-2.700	.039	.006	3	1
UCEC	GATA6 →	-0.167	-2.321	.020	.034	3	1
UCEC	Heregulin →	-0.155	-3.459	.005	.005	3	1
UCEC	MEK1 →	+0.427	+3.321	.009	.010	3	1
UCEC	MSH6 →	-0.487	-3.449	.001	.005	3	1
UCEC	Shc_pY317 →	-0.168	-2.000	.014	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by SLC7A5 expression — UCEC

Explore this box plot interactively →