SLC7A5

Across TCGA cell cohorts, SLC7A5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC7A5-associated genes across cancer lineages are GML, LGI1, and KRT71. Each is linked with SLC7A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A5-to-partner and partner-to-SLC7A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by SLC7A5-low versus SLC7A5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A5→partner) and Y-score (partner→SLC7A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.065	+4.152	.002	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.091	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRT71 →	+0.052	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	OR10R2 →	+1.948	+4.551	<.001	.004	3	1
BLOOD_Leukemia	IQCF5 →	+0.108	+5.786	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PRLHR →	+0.059	+4.947	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GML by SLC7A5 expression — BLOOD_Leukemia

Explore this box plot interactively →