SLC7A4

Across TCGA patient cohorts, SLC7A4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A4-associated genes across cancer lineages are TIGAR, ATM, and Caspase-7-cleavedD198. Each is linked with SLC7A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A4-to-partner and partner-to-SLC7A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by SLC7A4-low versus SLC7A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A4→partner) and Y-score (partner→SLC7A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.117	+1.689	.029	.007	3	2
UCEC	ATM →	-0.369	-1.986	.021	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+0.607	+1.720	.003	.025	3	2
UCEC	4E-BP1 →	+0.222	+2.614	.020	.005	3	2
UCEC	14-3-3_beta →	-0.097	-1.973	.006	.029	3	1
UCEC	eEF2 →	+0.382	+1.807	.002	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

TIGAR by SLC7A4 expression — UCEC

Explore this box plot interactively →