SLC7A4

Across TCGA cell cohorts, SLC7A4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,502 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SLC7A4-associated GO terms across cancer lineages are Pallium development, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Negative regulation of protein localization. Each is linked with SLC7A4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLC7A4-to-partner and partner-to-SLC7A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pallium development grouped by SLC7A4-low versus SLC7A4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A4→partner) and Y-score (partner→SLC7A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Pallium development →	+0.063	+1.051	.002	.003	3	6
LARGE_INTESTINE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.100	+0.548	<.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Negative regulation of protein localization →	+0.045	+0.454	<.001	.002	3	5
LUNG_SCLC	Cerebral cortex development →	+0.098	+1.435	<.001	<.001	3	5
SKIN	Organelle fusion →	+0.028	+0.881	<.001	.004	3	5
SOFT_TISSUE	mRNA transcription by RNA polymerase II →	+0.056	+0.385	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,502 associations by consensus.

Pallium development by SLC7A4 expression — LUNG_SCLC

Explore this box plot interactively →