SLC7A4

Across TCGA cell cohorts, SLC7A4 mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC7A4-associated genes across cancer lineages are HIGD2B, PRAMEF1, and TEX36. Each is linked with SLC7A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A4-to-partner and partner-to-SLC7A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD2B grouped by SLC7A4-low versus SLC7A4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A4→partner) and Y-score (partner→SLC7A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HIGD2B →	+0.036	+2.694	.006	.006	3	2
LUNG_SCLC	PRAMEF1 →	+0.038	+4.523	<.001	.003	3	1
LUNG_SCLC	TEX36 →	+0.201	+4.044	.004	.009	3	1
LUNG_SCLC	LCE1C →	+0.672	+4.643	<.001	.004	3	1
LUNG_SCLC	LCE1F →	+0.107	+4.643	<.001	.004	3	1
LARGE_INTESTINE	FRG1 →	+0.417	+3.364	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

HIGD2B by SLC7A4 expression — LARGE_INTESTINE

Explore this box plot interactively →