SLC7A1

Across TCGA pan-cancer cohorts, SLC7A1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLC7A1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC7A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC7A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where SLC7A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.766	0.518	.010	10	view →
LUAD	DFS	Quartile	II,III,IV	0.205	0.748	.031	4	view →
UCEC	DFS	Median	II,III,IV	0.882	0.533	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLC7A1–HNSC (DFS)

Open the HNSC breakdown →