SLC7A1

Across TCGA patient cohorts, SLC7A1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC7A1-associated genes across cancer lineages are Annexin-1, Smad3, and STAT3_pY705. Each is linked with SLC7A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A1-to-partner and partner-to-SLC7A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by SLC7A1-low versus SLC7A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A1→partner) and Y-score (partner→SLC7A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.535	+2.720	.003	.003	3	2
UCEC	Smad3 →	+0.134	+1.584	.010	.034	3	2
UCEC	STAT3_pY705 →	-0.388	-2.492	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.754	+2.019	<.001	.005	3	2
UCEC	eEF2 →	+0.321	+2.000	.009	.030	3	1
UCEC	EGFR_pY1068 →	-0.213	-1.440	.014	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Annexin-1 by SLC7A1 expression — UCEC

Explore this box plot interactively →