SLC7A1

Across TCGA cell cohorts, SLC7A1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC7A1-associated genes across cancer lineages are OR52H1, TAFA1, and PFN3. Each is linked with SLC7A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC7A1-to-partner and partner-to-SLC7A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52H1 grouped by SLC7A1-low versus SLC7A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC7A1→partner) and Y-score (partner→SLC7A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR52H1 →	+0.022	+3.084	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	PFN3 →	+0.091	+2.882	<.001	.005	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1
BLOOD_Leukemia	LYPD2 →	+0.068	+4.152	.001	.009	3	1
BLOOD_Leukemia	FAM24A →	+0.061	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR52H1 by SLC7A1 expression — LARGE_INTESTINE

Explore this box plot interactively →