SLC6A8

Across TCGA pan-cancer cohorts, SLC6A8 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLC6A8 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SLC6A8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC6A8 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where SLC6A8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.860	0.418	.001	30	view →
GBM	DFS	Median	All	0.485	0.819	.038	5	view →
CCRCC	DFS	Quartile	II,III,IV	0.125	0.856	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLC6A8–LSCC (DFS)

Open the LSCC breakdown →