SLC6A8

Across TCGA patient cohorts, SLC6A8 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A8-associated genes across cancer lineages are INPP4B, C-Raf, and 14-3-3_beta. Each is linked with SLC6A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A8-to-partner and partner-to-SLC6A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SLC6A8-low versus SLC6A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A8→partner) and Y-score (partner→SLC6A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.323	-2.115	.006	.017	3	2
UCEC	C-Raf →	+0.113	+1.502	.031	.030	3	2
UCEC	14-3-3_beta →	-0.107	-2.558	.003	.010	3	1
UCEC	eEF2 →	+0.290	+1.874	.027	.049	3	1
UCEC	EGFR_pY1068 →	-0.303	-2.247	<.001	.001	3	1
UCEC	eIF4E →	+0.192	+3.335	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

INPP4B by SLC6A8 expression — UCEC

Explore this box plot interactively →