SLC6A8

Across TCGA cell cohorts, SLC6A8 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A8-associated genes across cancer lineages are FOXB2, SH3GL2, and SAXO1. Each is linked with SLC6A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A8-to-partner and partner-to-SLC6A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXB2 grouped by SLC6A8-low versus SLC6A8-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A8→partner) and Y-score (partner→SLC6A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FOXB2 →	+0.013	+5.285	<.001	.003	3	1
LARGE_INTESTINE	SH3GL2 →	+1.096	+3.252	.006	.009	3	1
LARGE_INTESTINE	SAXO1 →	+0.047	+3.374	<.001	.005	3	1
LARGE_INTESTINE	INSL5 →	+0.311	+3.889	<.001	.001	3	1
LARGE_INTESTINE	CRYBA4 →	+0.311	+3.626	.006	.003	3	1
BLOOD_Leukemia	LCE2A →	+0.053	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXB2 by SLC6A8 expression — STOMACH

Explore this box plot interactively →