SLC6A7

Across TCGA pan-cancer cohorts, SLC6A7 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC6A7 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SLC6A7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC6A7 expression acts as an unfavorable survival marker.

LIHC, HNSC, and SARC are the cancer types where SLC6A7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.128	0.783	.001	36	view →
HNSC	DFS	Median	All	0.144	0.712	<.001	24	view →
SARC	DFS	Median	All	0.109	0.611	.030	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	3	view →
SKCM	DFS	Median	All	0.397	0.642	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC6A7–LIHC (OS)

Open the LIHC breakdown →