SLC6A7

Across TCGA patient cohorts, SLC6A7 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A7-associated genes across cancer lineages are eEF2, VEGFR2, and EGFR_pY1068. Each is linked with SLC6A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A7-to-partner and partner-to-SLC6A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SLC6A7-low versus SLC6A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A7→partner) and Y-score (partner→SLC6A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.313	+2.999	.029	.035	3	2
UCEC	VEGFR2 →	+0.323	+1.920	.006	.009	3	2
UCEC	EGFR_pY1068 →	-0.232	-2.999	.021	.035	3	1
UCEC	A-Raf_pS299 →	-0.125	-2.000	.009	.030	3	1
UCEC	GAPDH →	+0.455	+2.999	.035	.035	3	1
UCEC	IGFBP2 →	-0.701	-2.459	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eEF2 by SLC6A7 expression — UCEC

Explore this box plot interactively →