SLC6A7

Across TCGA cell cohorts, SLC6A7 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A7-associated genes across cancer lineages are Niraparib, AZD7969, and PARP_0108. Each is linked with SLC6A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A7-to-partner and partner-to-SLC6A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by SLC6A7-low versus SLC6A7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A7→partner) and Y-score (partner→SLC6A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.470	+2.646	.007	.047	3	1
LARGE_INTESTINE	AZD7969 →	+0.551	+2.649	.015	.046	3	1
LARGE_INTESTINE	PARP_0108 →	+0.999	+2.710	.001	.027	3	1
LARGE_INTESTINE	PARP_9482 →	+1.066	+2.710	<.001	.027	3	1
LARGE_INTESTINE	630600 →	+0.700	+2.649	.024	.046	3	1
LARGE_INTESTINE	LMP744 →	+0.686	+2.649	.043	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Niraparib by SLC6A7 expression — LARGE_INTESTINE

Explore this box plot interactively →