SLC6A6

Across TCGA patient cohorts, SLC6A6 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A6-associated genes across cancer lineages are eEF2, EGFR_pY1068, and TIGAR. Each is linked with SLC6A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A6-to-partner and partner-to-SLC6A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SLC6A6-low versus SLC6A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A6→partner) and Y-score (partner→SLC6A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.261	+2.321	.039	.033	3	2
UCEC	EGFR_pY1068 →	-0.264	-2.321	.002	.005	3	2
UCEC	TIGAR →	+0.108	+1.689	.045	.007	3	2
UCEC	ATM →	-0.480	-2.392	.002	<.001	3	2
UCEC	Chk2_pT68 →	-0.162	-2.212	.014	.010	3	2
UCEC	c-Jun_pS73 →	-0.130	-1.662	.020	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eEF2 by SLC6A6 expression — UCEC

Explore this box plot interactively →