SLC6A5

Across TCGA patient cohorts, SLC6A5 mutation is significantly associated with the RNA expression of many other genes, with 5,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A5-associated genes across cancer lineages are GINS3, WDHD1, and RFC5. Each is linked with SLC6A5 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC6A5-to-partner and partner-to-SLC6A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS3 grouped by SLC6A5-low versus SLC6A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A5→partner) and Y-score (partner→SLC6A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS3 →	+0.553	+2.523	<.001	<.001	3	5
UCEC	WDHD1 →	+0.535	+1.895	<.001	.001	3	5
LUAD	RFC5 →	+0.633	+3.271	<.001	<.001	3	5
LUAD	TMPO →	+0.545	+3.528	.001	.002	3	5
LUAD	STIL →	+0.613	+3.345	.001	.005	3	5
SKCM	EIF2S1 →	+0.470	+1.912	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,790 associations by consensus.

GINS3 by SLC6A5 expression — UCEC

Explore this box plot interactively →