SLC6A5

Across TCGA patient cohorts, SLC6A5 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A5-associated genes across cancer lineages are TFRC, ASNS, and PCNA. Each is linked with SLC6A5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC6A5-to-partner and partner-to-SLC6A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SLC6A5-low versus SLC6A5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A5→partner) and Y-score (partner→SLC6A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TFRC →	+0.905	+3.033	<.001	.017	3	4
COAD	ASNS →	+0.599	+3.330	.001	.005	3	4
UCEC	PCNA →	+0.238	+2.999	<.001	<.001	3	4
COAD	c-Kit →	-0.762	-3.321	.007	.009	3	3
LUAD	p27_pT198 →	+0.121	+2.824	.034	.034	3	3
COAD	PDCD4 →	-0.622	-3.000	.001	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

TFRC by SLC6A5 expression — COAD

Explore this box plot interactively →