SLC6A5

Across TCGA cell cohorts, SLC6A5 RNA expression is significantly associated with the go_rna of many other GO terms, with 323 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SLC6A5-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of ubiquitin protein ligase activity, and Adaptive immune response. Each is linked with SLC6A5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A5-to-partner and partner-to-SLC6A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by SLC6A5-low versus SLC6A5-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A5→partner) and Y-score (partner→SLC6A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.083	+0.009	.001	.004	3	3
LUNG_SCLC	Regulation of ubiquitin protein ligase activity →	+0.104	+0.180	.002	.005	3	3
LUNG_SCLC	Adaptive immune response →	-0.099	-0.240	<.001	.008	3	3
LUNG_SCLC	tRNA transcription by RNA polymerase III →	+0.098	+0.203	<.001	.001	3	3
LUNG_SCLC	Regulation of fibrinolysis →	-0.200	-0.169	<.001	.008	3	3
LUNG_SCLC	Regulation of wound healing →	-0.118	-0.190	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by SLC6A5 expression — BLOOD_Leukemia

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