SLC6A5

Across TCGA cell cohorts, SLC6A5 mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A5-associated genes across cancer lineages are AVP, POU6F1, and BORCS6. Each is linked with SLC6A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A5-to-partner and partner-to-SLC6A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by SLC6A5-low versus SLC6A5-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A5→partner) and Y-score (partner→SLC6A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AVP →	+0.028	+4.196	<.001	.006	3	2
SKIN	POU6F1 →	+0.538	+3.212	.009	.006	3	2
SKIN	BORCS6 →	+0.502	+3.299	.001	.004	3	2
LUNG_NSCLC_LUAD	MORC1 →	+0.122	+3.343	<.001	.005	3	2
LARGE_INTESTINE	SEL1L2 →	+0.025	+2.415	.001	.009	3	2
LARGE_INTESTINE	FAM177A1 →	+0.489	+2.043	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

AVP by SLC6A5 expression — BREAST

Explore this box plot interactively →