SLC6A4

Across TCGA patient cohorts, SLC6A4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,208 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SLC6A4-associated genes across cancer lineages are RASIP1, PON2, and PRR4. Each is linked with SLC6A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A4-to-partner and partner-to-SLC6A4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SLC6A4 versus RASIP1 in LUAD, with a Pearson correlation of 0.25.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A4→partner) and Y-score (partner→SLC6A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RASIP1 →	+0.442	+0.628	.002	<.001	3	1
LUAD	PON2 →	-0.514	-0.448	<.001	<.001	3	1
LUAD	PRR4 →	-0.462	-0.509	.007	<.001	3	1
LUAD	DENND10 →	-0.221	-0.371	<.001	.003	3	1
LUAD	RAMP3 →	+0.536	+0.424	.001	.006	3	1
LUAD	RNF17 →	-0.126	-0.593	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,208 associations by consensus.

SLC6A4 vs RASIP1 — LUAD

Explore this scatter interactively →