SLC6A4

Across TCGA patient cohorts, SLC6A4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A4-associated genes across cancer lineages are STAT3_pY705, eEF2, and JNK_pT183_Y185. Each is linked with SLC6A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A4-to-partner and partner-to-SLC6A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SLC6A4-low versus SLC6A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A4→partner) and Y-score (partner→SLC6A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.392	-1.678	<.001	.023	3	3
UCEC	eEF2 →	+0.458	+3.584	<.001	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.225	-3.234	<.001	<.001	3	2
UCEC	ATM →	-0.603	-3.446	<.001	.005	3	2
UCEC	Bax →	+0.316	+2.584	<.001	.010	3	2
UCEC	Di-Ras3 →	-0.123	-3.308	.030	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

STAT3_pY705 by SLC6A4 expression — UCEC

Explore this box plot interactively →