SLC6A4

Across TCGA cell cohorts, SLC6A4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,096 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC6A4-associated GO terms across cancer lineages are Regulation of TORC1 signaling, Epigenetic regulation of gene expression, and mRNA catabolic process. Each is linked with SLC6A4 in more than 6 cancer types. Because this analysis shows association rather than direction, both SLC6A4-to-partner and partner-to-SLC6A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of TORC1 signaling grouped by SLC6A4-low versus SLC6A4-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A4→partner) and Y-score (partner→SLC6A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of TORC1 signaling →	+0.058	+0.071	<.001	.004	3	7
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.074	+0.229	<.001	.009	3	6
LUNG_NSCLC_LUSC	mRNA catabolic process →	+0.048	+0.083	<.001	.001	3	6
LIVER	Regulation of serotonin secretion →	+1.388	+2.259	.008	<.001	3	6
PANCREAS	Regulation of RNA splicing →	+0.067	+0.071	.001	.005	3	6
CNS	Regulation of DNA-templated transcription elongation →	+0.040	+0.075	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,096 associations by consensus.

Regulation of TORC1 signaling by SLC6A4 expression — PANCREAS

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