SLC6A3

Across TCGA patient cohorts, SLC6A3 mutation is significantly associated with the RNA expression of many other genes, with 3,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A3-associated genes across cancer lineages are UHRF1, RNU4-42P, and RPL30P10. Each is linked with SLC6A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A3-to-partner and partner-to-SLC6A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by SLC6A3-low versus SLC6A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A3→partner) and Y-score (partner→SLC6A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.730	+2.050	<.001	<.001	3	3
LUAD	RNU4-42P →	+0.814	+5.217	<.001	.007	3	3
LUAD	RPL30P10 →	+0.262	+5.099	<.001	.008	3	3
GBM	RNU6-254P →	+0.524	+4.969	<.001	.009	3	3
UCEC	CDCA8 →	+0.542	+2.364	.001	<.001	3	3
COAD	SNORA10B →	+0.285	+2.956	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,088 associations by consensus.

UHRF1 by SLC6A3 expression — UCEC

Explore this box plot interactively →