SLC6A3

Across TCGA patient cohorts, SLC6A3 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A3-associated genes across cancer lineages are Cyclin-B1, ASNS, and 4E-BP1. Each is linked with SLC6A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC6A3-to-partner and partner-to-SLC6A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SLC6A3-low versus SLC6A3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A3→partner) and Y-score (partner→SLC6A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.746	+3.000	.005	.035	3	4
UCEC	ASNS →	+0.303	+1.152	.003	.048	3	4
UCEC	4E-BP1 →	+0.234	+2.222	.002	.009	3	4
COAD	Cyclin-E2 →	+0.256	+2.832	.025	.034	3	3
SKCM	FoxM1 →	+0.179	+1.662	.013	.011	3	3
COAD	SCD →	+0.201	+3.212	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Cyclin-B1 by SLC6A3 expression — COAD

Explore this box plot interactively →